Conditions That Qualify for Disability

Plain-English condition guides mapped to SSA Blue Book criteria. Review listing references, evidence expectations, and documentation checklists before you file.

All Cancer Heart & Blood Digestive Endocrine Genitourinary Blood Disorders Immune System Mental Health Multiple Systems Musculoskeletal Neurological Respiratory Skin Senses & Speech

Border colors indicate category. CAL = Compassionate Allowance — claims may be processed faster by SSA.

Down Syndrome

Multiple SystemsListing 10.06

Down syndrome is a genetic condition caused by the presence of an extra copy of chromosome 21. SSA evaluates disability claims for Down syndrome under Listing 10.06 in the "Multiple Body Systems" category of the Blue Book. Non-mosaic Down syndrome — which includes both chromosome 21 trisomy and chromosome 21 translocation — is specifically listed, meaning SSA will consider whether your medical records document the diagnosis according to the criteria in that listing.

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